Assay Detail
Binding
CHEMBL4355634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Aldose reductase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.10 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69956 | — | — | 1 | 8.68 |
| CHEMBL73560 | — | — | 1 | 8.49 |
| CHEMBL68580 | — | — | 1 | 8.28 |
| CHEMBL4436968 | — | — | 1 | 7.70 |
| CHEMBL4458061 | — | — | 1 | 7.34 |
| CHEMBL69350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69956 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL73560 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL68580 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4436968 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4458061 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL69350 | — | IC50 | <= | 10.0 | nM | - |