Assay Detail
Binding
CHEMBL4355635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placenta Aldose reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.35 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 8.68 |
| CHEMBL20169 | — | — | 1 | 8.51 |
| CHEMBL143234 | — | — | 1 | 8.49 |
| CHEMBL21091 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL20169 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL143234 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL21091 | — | IC50 | = | 19.0 | nM | 7.72 |