Assay Detail
Binding
CHEMBL4355679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC1 expressed in HEK293T/17 cells using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence-based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.59 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447715 | — | — | 1 | 7.47 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 6.44 |
| CHEMBL4469488 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447715 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4469488 | — | IC50 | = | 1390.0 | nM | 5.86 |