Assay Detail
Binding
CHEMBL4355756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substrate measured every 60 sec for 45 mins by fluorescence spectrophotometry
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 5.58 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4108795 | — | — | 1 | 6.10 |
| CHEMBL4443587 | — | — | 1 | 5.89 |
| CHEMBL4473252 | — | — | 1 | 5.80 |
| CHEMBL4483089 | — | — | 1 | 5.44 |
| CHEMBL4113501 | — | — | 1 | 5.41 |
| CHEMBL3681909 | — | — | 1 | 5.35 |
| CHEMBL4112447 | — | — | 1 | 5.09 |
| CHEMBL4554360 | — | — | 1 | - |
| CHEMBL4113968 | — | — | 1 | - |
| CHEMBL4448352 | — | — | 1 | - |
| CHEMBL4456515 | — | — | 1 | - |
| CHEMBL4541985 | — | — | 1 | - |
| CHEMBL3897809 | — | — | 1 | - |
| CHEMBL4436228 | — | — | 1 | - |
| CHEMBL4513613 | — | — | 1 | - |
| CHEMBL4111094 | — | — | 1 | - |
| CHEMBL4561925 | — | — | 1 | - |
| CHEMBL4440249 | — | — | 1 | - |
| CHEMBL4107048 | — | — | 1 | - |
| CHEMBL4520749 | — | — | 1 | - |
| CHEMBL4519186 | — | — | 1 | - |
| CHEMBL4516713 | — | — | 1 | - |
| CHEMBL4449194 | — | — | 1 | - |
| CHEMBL4586062 | — | — | 1 | - |
| CHEMBL4576476 | — | — | 1 | - |
| CHEMBL4583010 | — | — | 1 | - |
| CHEMBL4444446 | — | — | 1 | - |
| CHEMBL4552866 | — | — | 1 | - |
| CHEMBL4454814 | — | — | 1 | - |
| CHEMBL1213603 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4108795 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL4443587 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4473252 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4483089 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL4113501 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL3681909 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL4112447 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL4436228 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4453820 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4513613 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4111094 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4561925 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4440249 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4113968 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4546366 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4470857 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4110365 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4545886 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4454942 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3686728 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4578331 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4530018 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4476839 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4465511 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4516713 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1213603 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4454814 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4552866 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4444446 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4583010 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4576476 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4586062 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4449194 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3897809 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4519186 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4520749 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4107048 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4554360 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4448352 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4456515 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4541985 | — | Ki | > | 10000.0 | nM | - |