Assay Detail
ADMET
CHEMBL4355897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.43 | 4.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.53 |
| CHEMBL1765593 | — | — | 1 | 4.48 |
| CHEMBL4454354 | — | — | 1 | 4.28 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 29530.0 | nM | 4.53 |
| CHEMBL1765593 | — | IC50 | = | 33210.0 | nM | 4.48 |
| CHEMBL4454354 | — | IC50 | = | 53140.0 | nM | 4.28 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | IC50 | > | 100000.0 | nM | - |