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Assay Detail

CHEMBL4355970

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of RNA-dependent RNA polymerase in Zika virus FSS13025/2010 infected in African green monkey Vero cells assessed as antiviral activity measured 48 hrs post infection by plaque assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zika virus
Cell Type Vero
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NS5 (CHEMBL4523952)
Type SINGLE PROTEIN
Organism Zika virus

Publication

Drugs for the Treatment of Zika Virus Infection.
Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R.
J Med Chem (2020) 63 : 470 -489
PubMed 31549836 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.86 6.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1630221 1 6.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1630221 EC50 = 137.0 nM 6.86