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Assay Detail

CHEMBL4356005

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Binding
Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC59 infected in African green monkey Vero cells assessed as antiviral activity measured 96 hrs post infection by plaque assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zika virus
Cell Type Vero
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NS5 (CHEMBL4523952)
Type SINGLE PROTEIN
Organism Zika virus

Publication

Drugs for the Treatment of Zika Virus Infection.
Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R.
J Med Chem (2020) 63 : 470 -489
PubMed 31549836 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.03 7.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4589719 1 7.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4589719 EC50 = 94.0 nM 7.03