Assay Detail
Binding
CHEMBL4356129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as apparent inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.47 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | 4.47 |
| CHEMBL4584081 | — | — | 1 | - |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL4584081 | — | Ki | - | — | - | |
| CHEMBL3545369 | EPACADOSTAT | Ki | - | — | - |