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Assay Detail

CHEMBL4356357

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of human plasmin assessed as reduction in hydrolytic activity using S-2251 as substrate by spectrophotometric method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Plasminogen (CHEMBL1801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.
Steinmetzer T, Pilgram O, Wenzel BM, Wiedemeyer SJA.
J Med Chem (2020) 63 : 1445 -1472
PubMed 31658420 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.72 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL87563 GABEXATE 3.0 1 5.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL87563 GABEXATE Ki = 1900.0 nM 5.72