Assay Detail

CHEMBL4356411

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Binding

Inhibition of 26S proteasome (unknown origin) incubated for 2 hrs by proteasome Ub-Rho cleavage assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors.

Schauer NJ, Magin RS, Liu X, Doherty LM, Buhrlage SJ.
J Med Chem (2020) 63 : 2731 -2750
PubMed 31682427 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.19	5.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4441423	—	—	1	5.19
CHEMBL158037	—	—	1	5.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4441423	—	EC50	=	6400.0	nM	5.19
CHEMBL158037	—	EC50	=	6500.0	nM	5.19