Assay Detail
Functional
CHEMBL4356679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7:5C cells assessed as reduction in cell viability incubated for 7 days by Hoechst 33258 dye based assay
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 9.38 | 10.06 |
| pIC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447374 | — | — | 1 | 10.06 |
| CHEMBL4538085 | — | — | 1 | 9.93 |
| CHEMBL4564385 | — | — | 1 | 9.92 |
| CHEMBL4436415 | — | — | 1 | 9.85 |
| CHEMBL4586663 | — | — | 1 | 9.79 |
| CHEMBL4547439 | — | — | 1 | 9.74 |
| CHEMBL4515212 | — | — | 1 | 9.58 |
| CHEMBL4527655 | — | — | 1 | 9.58 |
| CHEMBL4441662 | — | — | 1 | 9.53 |
| CHEMBL4533964 | — | — | 1 | 9.46 |
| CHEMBL4578883 | — | — | 1 | 9.44 |
| CHEMBL4483006 | — | — | 1 | 9.42 |
| CHEMBL4524872 | — | — | 1 | 9.35 |
| CHEMBL4532671 | — | — | 1 | 9.02 |
| CHEMBL4436707 | — | — | 1 | 9.00 |
| CHEMBL4440649 | — | — | 1 | 8.97 |
| CHEMBL4516021 | — | — | 1 | 8.89 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.76 |
| CHEMBL4543096 | — | — | 1 | 8.67 |
| CHEMBL4448178 | — | — | 1 | 8.55 |
| CHEMBL4562548 | — | — | 1 | - |
| CHEMBL4464171 | — | — | 1 | - |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447374 | — | IC50 | = | 0.0871 | nM | 10.06 |
| CHEMBL4538085 | — | IC50 | = | 0.1175 | nM | 9.93 |
| CHEMBL4564385 | — | IC50 | = | 0.1202 | nM | 9.92 |
| CHEMBL4436415 | — | IC50 | = | 0.1413 | nM | 9.85 |
| CHEMBL4586663 | — | IC50 | = | 0.1622 | nM | 9.79 |
| CHEMBL4547439 | — | IC50 | = | 0.182 | nM | 9.74 |
| CHEMBL4515212 | — | IC50 | = | 0.263 | nM | 9.58 |
| CHEMBL4527655 | — | IC50 | = | 0.263 | nM | 9.58 |
| CHEMBL4441662 | — | IC50 | = | 0.2951 | nM | 9.53 |
| CHEMBL4533964 | — | IC50 | = | 0.3467 | nM | 9.46 |
| CHEMBL4578883 | — | IC50 | = | 0.3631 | nM | 9.44 |
| CHEMBL4483006 | — | IC50 | = | 0.3802 | nM | 9.42 |
| CHEMBL4524872 | — | IC50 | = | 0.4467 | nM | 9.35 |
| CHEMBL4532671 | — | IC50 | = | 0.955 | nM | 9.02 |
| CHEMBL4436707 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4440649 | — | IC50 | = | 1.072 | nM | 8.97 |
| CHEMBL4516021 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 1.738 | nM | 8.76 |
| CHEMBL4543096 | — | IC50 | = | 2.138 | nM | 8.67 |
| CHEMBL4448178 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL4562548 | — | pIC50 | - | — | - | |
| CHEMBL4464171 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL81 | RALOXIFENE | pIC50 | - | — | - |