Assay Detail
Binding
CHEMBL4357002
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Inhibition of bacterial OXA-48 using nitrocefin as substrate preincubated for 15 mins followed by susbtrate addition and measured after 10 mins by spectrophotometric method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.81 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451971 | — | — | 1 | 6.54 |
| CHEMBL4588079 | — | — | 1 | 6.45 |
| CHEMBL4463697 | — | — | 1 | 6.38 |
| CHEMBL4473993 | — | — | 1 | 6.34 |
| CHEMBL4580844 | — | — | 1 | 6.30 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 6.26 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 6.26 |
| CHEMBL4464659 | — | — | 1 | 6.24 |
| CHEMBL4516963 | — | — | 1 | 6.18 |
| CHEMBL4584705 | — | — | 1 | 6.17 |
| CHEMBL4521690 | — | — | 1 | 5.82 |
| CHEMBL4586683 | — | — | 1 | 5.80 |
| CHEMBL4541117 | — | — | 1 | 5.75 |
| CHEMBL4530583 | — | — | 1 | 5.75 |
| CHEMBL4442208 | — | — | 1 | 5.65 |
| CHEMBL4472905 | — | — | 1 | 5.50 |
| CHEMBL4439299 | — | — | 1 | 5.12 |
| CHEMBL4513988 | — | — | 1 | 4.75 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 4.52 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451971 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4588079 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL4463697 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4473993 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL4580844 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4464659 | — | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL4516963 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL4584705 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4521690 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4586683 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4541117 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4530583 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4442208 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4472905 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4439299 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL4513988 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3317857 | VABORBACTAM | IC50 | = | 38800.0 | nM | 4.41 |