Assay Detail
Binding
CHEMBL4357003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bacterial VIM-2 using nitrocefin as substrate preincubated for 15 mins followed by susbtrate addition and measured after 10 mins by spectrophotometric method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464659 | — | — | 1 | 8.70 |
| CHEMBL4463697 | — | — | 1 | 7.70 |
| CHEMBL4516963 | — | — | 1 | 7.09 |
| CHEMBL4586683 | — | — | 1 | 7.07 |
| CHEMBL4580844 | — | — | 1 | 6.96 |
| CHEMBL4584705 | — | — | 1 | 6.89 |
| CHEMBL4442208 | — | — | 1 | 6.82 |
| CHEMBL4541117 | — | — | 1 | 6.57 |
| CHEMBL4473993 | — | — | 1 | 6.32 |
| CHEMBL4451971 | — | — | 1 | 6.31 |
| CHEMBL4588079 | — | — | 1 | 6.23 |
| CHEMBL4439299 | — | — | 1 | 5.85 |
| CHEMBL4521690 | — | — | 1 | 5.82 |
| CHEMBL4530583 | — | — | 1 | 5.80 |
| CHEMBL4513988 | — | — | 1 | 5.78 |
| CHEMBL4472905 | — | — | 1 | 5.62 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | - |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | - |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464659 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4463697 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4516963 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4586683 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4580844 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4584705 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4442208 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4541117 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4473993 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL4451971 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL4588079 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL4439299 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4521690 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4530583 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4513988 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4472905 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1689063 | AVIBACTAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317857 | VABORBACTAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL777 | CLAVULANIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL404 | TAZOBACTAM | IC50 | > | 100000.0 | nM | - |