Assay Detail
Binding
CHEMBL4357008
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Inhibition of bacterial SHV-5 using cefotaxime as substrate preincubated for 15 mins followed by susbtrate addition and measured after 10 mins by spectrophotometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.88 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463697 | — | — | 1 | 9.40 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.92 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 7.89 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.82 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463697 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3317857 | VABORBACTAM | IC50 | = | 440.0 | nM | 6.36 |