Assay Detail
Functional
CHEMBL4357189
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Potentiation of cisplatin-induced cytotoxicity against human HeLa cells assessed as cisplatin IC50 after 48 hrs by MTT assay (Rvb = 6.3 +/- 0.8 microM)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.13 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4581126 | — | — | 1 | 6.24 |
| CHEMBL4587036 | — | — | 1 | 6.02 |
| CHEMBL4460318 | — | — | 1 | - |
| CHEMBL4447701 | — | — | 1 | - |
| CHEMBL4453814 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4581126 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4587036 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4460318 | — | IC50 | - | — | - | |
| CHEMBL4447701 | — | IC50 | - | — | - | |
| CHEMBL4453814 | — | IC50 | - | — | - |