Assay Detail
Binding
CHEMBL4357205
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Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.97 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587036 | — | — | 1 | 8.60 |
| CHEMBL4581126 | — | — | 1 | 8.37 |
| CHEMBL4447701 | — | — | 1 | 8.19 |
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 7.82 |
| CHEMBL4453814 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587036 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4581126 | — | IC50 | = | 4.28 | nM | 8.37 |
| CHEMBL4447701 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL2141296 | IXAZOMIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4453814 | — | IC50 | = | 136.0 | nM | 6.87 |