Assay Detail
Binding
CHEMBL4357464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 (CHEMBL3883319) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.25 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1723511 | — | — | 1 | 6.89 |
| CHEMBL4469620 | — | — | 1 | 6.70 |
| CHEMBL487046 | — | — | 1 | 6.70 |
| CHEMBL4443974 | — | — | 1 | 6.60 |
| CHEMBL87223 | AMINOQUINURIDE | 2.0 | 1 | 5.30 |
| CHEMBL1178292 | — | — | 1 | 5.30 |
| CHEMBL1967787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1723511 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4469620 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL487046 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4443974 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL87223 | AMINOQUINURIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1178292 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1967787 | — | IC50 | > | 300000.0 | nM | - |