Assay Detail
Binding
CHEMBL4357657
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Inhibition of recombinant Plasmodium falciparum Plasmepsin 1
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.55 | 7.30 |
| Ki | 1 | 9.10 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176888 | — | — | 1 | 9.10 |
| CHEMBL4225824 | — | — | 1 | 7.30 |
| CHEMBL4556003 | — | — | 1 | 7.00 |
| CHEMBL4537622 | — | — | 1 | 6.98 |
| CHEMBL4530972 | — | — | 1 | 6.95 |
| CHEMBL4470715 | — | — | 1 | 6.91 |
| CHEMBL4516552 | — | — | 1 | 6.55 |
| CHEMBL1233569 | — | — | 1 | 6.18 |
| CHEMBL1230705 | — | — | 1 | 5.95 |
| CHEMBL4543535 | — | — | 1 | 5.93 |
| CHEMBL4435432 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176888 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL4225824 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4556003 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4537622 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4530972 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4470715 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL4516552 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1233569 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL1230705 | — | IC50 | = | 1123.0 | nM | 5.95 |
| CHEMBL4543535 | — | IC50 | = | 1162.0 | nM | 5.93 |
| CHEMBL4435432 | — | IC50 | = | 2000.0 | nM | 5.70 |