Assay Detail
Binding
CHEMBL4357658
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Inhibition of human cathepsin D
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.36 | 8.05 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257594 | — | — | 1 | 8.05 |
| CHEMBL121769 | — | — | 1 | 5.89 |
| CHEMBL4556003 | — | — | 1 | 5.70 |
| CHEMBL4541926 | — | — | 1 | 5.69 |
| CHEMBL558459 | HYDRAZOBENZENE | — | 1 | 5.62 |
| CHEMBL4580614 | — | — | 1 | 5.36 |
| CHEMBL4444927 | — | — | 1 | 5.28 |
| CHEMBL4448566 | — | — | 1 | 5.16 |
| CHEMBL4581955 | — | — | 1 | 4.82 |
| CHEMBL4518375 | — | — | 1 | 4.74 |
| CHEMBL1233569 | — | — | 1 | 4.69 |
| CHEMBL4225824 | — | — | 1 | 4.68 |
| CHEMBL4469961 | — | — | 1 | 4.06 |
| CHEMBL176888 | — | — | 1 | - |
| CHEMBL1233097 | — | — | 1 | - |
| CHEMBL4554448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257594 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL121769 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4556003 | — | IC50 | = | 1997.0 | nM | 5.70 |
| CHEMBL4541926 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL558459 | HYDRAZOBENZENE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4580614 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4444927 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4448566 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4581955 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4518375 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL1233569 | — | IC50 | = | 20362.0 | nM | 4.69 |
| CHEMBL4225824 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4469961 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL176888 | — | Ki | > | 200.0 | nM | - |
| CHEMBL1233097 | — | IC50 | > | 1300000.0 | nM | - |
| CHEMBL4554448 | — | IC50 | = | 262000.0 | nM | - |