Assay Detail
Binding
CHEMBL4357670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin E
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.89 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448566 | — | — | 1 | 5.40 |
| CHEMBL4541926 | — | — | 1 | 5.15 |
| CHEMBL4556003 | — | — | 1 | 5.12 |
| CHEMBL4581955 | — | — | 1 | 4.70 |
| CHEMBL4469961 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448566 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4541926 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL4556003 | — | IC50 | = | 7547.0 | nM | 5.12 |
| CHEMBL4581955 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4469961 | — | IC50 | = | 87000.0 | nM | 4.06 |