Assay Detail
Binding
CHEMBL4357707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tracer 222 binding to recombinant human His-tagged TAK1 (437 to 504 residues) expressed in baculovirus expression system using tyrosine-4 peptide as substrate incubated for 60 mins by Lanthascreen assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 7 (CHEMBL5776) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.17 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883384 | — | — | 1 | 7.30 |
| CHEMBL4538743 | — | — | 1 | 6.65 |
| CHEMBL4574265 | — | — | 1 | 6.26 |
| CHEMBL4562024 | — | — | 1 | 5.83 |
| CHEMBL4563120 | — | — | 1 | 5.72 |
| CHEMBL4442889 | — | — | 1 | 5.26 |
| CHEMBL4569421 | — | — | 1 | - |
| CHEMBL4462060 | — | — | 1 | - |
| CHEMBL4460150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883384 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4538743 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4574265 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL4562024 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4563120 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4442889 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL4569421 | — | IC50 | - | — | - | |
| CHEMBL4462060 | — | IC50 | - | — | - | |
| CHEMBL4460150 | — | IC50 | - | — | - |