Assay Detail
Functional
CHEMBL4357709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCC827 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer glo assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515441 | — | — | 1 | 6.30 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | - |
| CHEMBL4548584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515441 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL217092 | SARACATINIB | Inhibition | - | % | - | |
| CHEMBL4548584 | — | Inhibition | - | % | - |