Assay Detail
Binding
CHEMBL4358399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substrate measured after 1 hr by kinase-glo assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 9.52 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 9.96 |
| CHEMBL4455710 | — | — | 1 | 9.77 |
| CHEMBL4470122 | — | — | 1 | 9.77 |
| CHEMBL4475217 | — | — | 1 | 9.72 |
| CHEMBL4440406 | — | — | 1 | 9.70 |
| CHEMBL4534475 | — | — | 1 | 9.70 |
| CHEMBL4516974 | — | — | 1 | 9.70 |
| CHEMBL4439080 | — | — | 1 | 9.66 |
| CHEMBL4437362 | — | — | 1 | 9.64 |
| CHEMBL4577573 | — | — | 1 | 9.64 |
| CHEMBL4580837 | — | — | 1 | 9.62 |
| CHEMBL4444638 | — | — | 1 | 9.55 |
| CHEMBL4449613 | — | — | 1 | 9.52 |
| CHEMBL4213353 | — | — | 1 | 9.51 |
| CHEMBL4536505 | — | — | 1 | 9.46 |
| CHEMBL4441605 | — | — | 1 | 9.43 |
| CHEMBL4461136 | — | — | 1 | 8.72 |
| CHEMBL573339 | PI-103 | — | 1 | 8.36 |
| CHEMBL1765463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218576 | COPANLISIB | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL4455710 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL4470122 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL4475217 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4440406 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4534475 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4516974 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4439080 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4437362 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4577573 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4580837 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL4444638 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4449613 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4213353 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL4536505 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL4441605 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL4461136 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL573339 | PI-103 | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1765463 | — | IC50 | > | 5.0 | nM | - |