Assay Detail
ADMET
CHEMBL4358762
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Cytotoxicity against human MRC5 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4,6-O-Thenylidene-β-d-glucopyranoside-(2″-acetamido, 3″-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4'-demethylepipodophyllotoxin as Potential Less Toxic Antitumor Candidate Drugs by Reducing DNA Damage and Less Inhibition of PI3K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.78 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572208 | — | — | 1 | 4.91 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 4.91 |
| CHEMBL4459546 | — | — | 1 | 4.84 |
| CHEMBL4525941 | — | — | 1 | 4.83 |
| CHEMBL4583918 | — | — | 1 | 4.80 |
| CHEMBL4546855 | — | — | 1 | 4.59 |
| CHEMBL4519466 | — | — | 1 | 4.59 |
| CHEMBL4452374 | — | — | 1 | - |
| CHEMBL4455564 | — | — | 1 | - |
| CHEMBL4439502 | — | — | 1 | - |
| CHEMBL4467352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572208 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4459546 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4525941 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4583918 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4546855 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL4519466 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL4452374 | — | IC50 | = | 123200.0 | nM | - |
| CHEMBL4455564 | — | IC50 | = | 133100.0 | nM | - |
| CHEMBL4439502 | — | IC50 | = | 122100.0 | nM | - |
| CHEMBL4467352 | — | IC50 | = | 124200.0 | nM | - |