Assay Detail
Functional
CHEMBL4358768
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4,6-O-Thenylidene-β-d-glucopyranoside-(2″-acetamido, 3″-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4'-demethylepipodophyllotoxin as Potential Less Toxic Antitumor Candidate Drugs by Reducing DNA Damage and Less Inhibition of PI3K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.38 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583918 | — | — | 1 | 6.00 |
| CHEMBL4572208 | — | — | 1 | 5.82 |
| CHEMBL4525941 | — | — | 1 | 5.70 |
| CHEMBL4459546 | — | — | 1 | 5.60 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 4.83 |
| CHEMBL4519466 | — | — | 1 | 4.30 |
| CHEMBL4452374 | — | — | 1 | - |
| CHEMBL4455564 | — | — | 1 | - |
| CHEMBL4546855 | — | — | 1 | - |
| CHEMBL4439502 | — | — | 1 | - |
| CHEMBL4467352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583918 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4572208 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4525941 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4459546 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4519466 | — | IC50 | = | 50300.0 | nM | 4.30 |
| CHEMBL4452374 | — | IC50 | = | 134100.0 | nM | - |
| CHEMBL4455564 | — | IC50 | = | 158200.0 | nM | - |
| CHEMBL4546855 | — | IC50 | = | 172200.0 | nM | - |
| CHEMBL4439502 | — | IC50 | = | 152200.0 | nM | - |
| CHEMBL4467352 | — | IC50 | = | 155300.0 | nM | - |