Assay Detail
Binding
CHEMBL4358808
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Binding affinity to recombinant human His-tagged BRD9 (134 to 239 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by isothermal titration calorimetry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.94 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823478 | — | — | 1 | 8.03 |
| CHEMBL3769507 | — | — | 1 | 7.43 |
| CHEMBL3823101 | — | — | 1 | 7.33 |
| CHEMBL4065619 | — | — | 1 | 7.09 |
| CHEMBL3133807 | — | — | 1 | 6.94 |
| CHEMBL408982 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823478 | — | Kd | = | 9.4 | nM | 8.03 |
| CHEMBL3769507 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL3823101 | — | Kd | = | 47.0 | nM | 7.33 |
| CHEMBL4065619 | — | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL3133807 | — | Kd | = | 114.0 | nM | 6.94 |
| CHEMBL408982 | — | Kd | = | 16000.0 | nM | 4.80 |