Assay Detail
Binding
CHEMBL4358815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel β- and γ-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.63 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510924 | — | — | 1 | 9.66 |
| CHEMBL4299851 | PIFLUFOLASTAT | 4.0 | 1 | 8.81 |
| CHEMBL4590944 | — | — | 1 | 8.40 |
| CHEMBL4461865 | — | — | 1 | 7.96 |
| CHEMBL4513630 | — | — | 1 | 7.92 |
| CHEMBL4445179 | — | — | 1 | 7.78 |
| CHEMBL4471968 | — | — | 1 | 6.97 |
| CHEMBL4466904 | — | — | 1 | 6.81 |
| CHEMBL4558538 | — | — | 1 | 6.71 |
| CHEMBL4586744 | — | — | 1 | 6.55 |
| CHEMBL4457563 | — | — | 1 | 6.40 |
| CHEMBL4453028 | — | — | 1 | - |
| CHEMBL4439962 | — | — | 1 | - |
| CHEMBL4550529 | — | — | 1 | - |
| CHEMBL4459755 | — | — | 1 | - |
| CHEMBL4459899 | — | — | 1 | - |
| CHEMBL4514701 | — | — | 1 | - |
| CHEMBL4588782 | — | — | 1 | - |
| CHEMBL4524986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510924 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4299851 | PIFLUFOLASTAT | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL4590944 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL4461865 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4513630 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL4445179 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4471968 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4466904 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4558538 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4586744 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL4457563 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL4453028 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4439962 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4550529 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4459755 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4459899 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4514701 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4588782 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4524986 | — | IC50 | > | 1000.0 | nM | - |