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Assay Detail

CHEMBL4358986

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]CCK-8s from human CCKA incubated for 60 mins by scintillation counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholecystokinin receptor type A (CHEMBL1901)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease.
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, de Jonghe S, Daelemans D, Naesens L, Brea J, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Radan M, Djikic T, Nikolic K, Pallàs M, Callado LF, Escolano C.
J Med Chem (2020) 63 : 3610 -3633
PubMed 32150414 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.23 5.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4450506 1 5.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4450506 IC50 = 5940.0 nM 5.23