Assay Detail
Binding
CHEMBL4359198
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Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 10.43 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4563742 | — | — | 1 | 10.96 |
| CHEMBL4471986 | — | — | 1 | 10.93 |
| CHEMBL4533823 | — | — | 1 | 10.89 |
| CHEMBL4531684 | — | — | 1 | 10.87 |
| CHEMBL4436027 | — | — | 1 | 10.78 |
| CHEMBL4567354 | — | — | 1 | 10.70 |
| CHEMBL4483702 | — | — | 1 | 10.70 |
| CHEMBL4440257 | — | — | 1 | 10.53 |
| CHEMBL4561734 | — | — | 1 | 10.53 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 10.49 |
| CHEMBL4548808 | — | — | 1 | 10.38 |
| CHEMBL3360467 | — | — | 1 | 10.36 |
| CHEMBL4549709 | — | — | 1 | 10.27 |
| CHEMBL4448604 | — | — | 1 | 10.26 |
| CHEMBL4472037 | — | — | 1 | 10.09 |
| CHEMBL4466702 | — | — | 1 | 9.83 |
| CHEMBL4446161 | — | — | 1 | 9.61 |
| CHEMBL4579455 | — | — | 1 | 9.52 |
| CHEMBL4465921 | — | — | 1 | - |
| CHEMBL4444885 | — | — | 1 | - |
| CHEMBL4476378 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4563742 | — | EC50 | = | 0.011 | nM | 10.96 |
| CHEMBL4471986 | — | EC50 | = | 0.0117 | nM | 10.93 |
| CHEMBL4533823 | — | EC50 | = | 0.0129 | nM | 10.89 |
| CHEMBL4531684 | — | EC50 | = | 0.0135 | nM | 10.87 |
| CHEMBL4436027 | — | EC50 | = | 0.0167 | nM | 10.78 |
| CHEMBL4567354 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4483702 | — | EC50 | = | 0.0201 | nM | 10.70 |
| CHEMBL4440257 | — | EC50 | = | 0.0293 | nM | 10.53 |
| CHEMBL4561734 | — | EC50 | = | 0.0297 | nM | 10.53 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.0324 | nM | 10.49 |
| CHEMBL4548808 | — | EC50 | = | 0.0414 | nM | 10.38 |
| CHEMBL3360467 | — | EC50 | = | 0.044 | nM | 10.36 |
| CHEMBL4549709 | — | EC50 | = | 0.0531 | nM | 10.27 |
| CHEMBL4448604 | — | EC50 | = | 0.055 | nM | 10.26 |
| CHEMBL4472037 | — | EC50 | = | 0.0807 | nM | 10.09 |
| CHEMBL4466702 | — | EC50 | = | 0.1479 | nM | 9.83 |
| CHEMBL4446161 | — | EC50 | = | 0.2483 | nM | 9.61 |
| CHEMBL4579455 | — | EC50 | = | 0.302 | nM | 9.52 |
| CHEMBL4465921 | — | EC50 | = | 0.0099 | nM | - |
| CHEMBL4444885 | — | EC50 | = | 0.0091 | nM | - |
| CHEMBL4476378 | — | EC50 | = | 0.0099 | nM | - |