Assay Detail
Binding
CHEMBL4359199
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Inhibition of NS5A in HCV genotype 1b infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 10.66 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579455 | — | — | 1 | 11.00 |
| CHEMBL4549709 | — | — | 1 | 10.85 |
| CHEMBL4436027 | — | — | 1 | 10.82 |
| CHEMBL4440257 | — | — | 1 | 10.77 |
| CHEMBL4561734 | — | — | 1 | 10.69 |
| CHEMBL4548808 | — | — | 1 | 10.66 |
| CHEMBL4472037 | — | — | 1 | 10.55 |
| CHEMBL4466702 | — | — | 1 | 10.55 |
| CHEMBL4446161 | — | — | 1 | 10.09 |
| CHEMBL3360467 | — | — | 1 | - |
| CHEMBL4444885 | — | — | 1 | - |
| CHEMBL4483702 | — | — | 1 | - |
| CHEMBL4465921 | — | — | 1 | - |
| CHEMBL4567354 | — | — | 1 | - |
| CHEMBL4448604 | — | — | 1 | - |
| CHEMBL4533823 | — | — | 1 | - |
| CHEMBL4563742 | — | — | 1 | - |
| CHEMBL4531684 | — | — | 1 | - |
| CHEMBL4476378 | — | — | 1 | - |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | - |
| CHEMBL4471986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579455 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4549709 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL4436027 | — | EC50 | = | 0.0151 | nM | 10.82 |
| CHEMBL4440257 | — | EC50 | = | 0.0171 | nM | 10.77 |
| CHEMBL4561734 | — | EC50 | = | 0.0203 | nM | 10.69 |
| CHEMBL4548808 | — | EC50 | = | 0.0217 | nM | 10.66 |
| CHEMBL4472037 | — | EC50 | = | 0.0284 | nM | 10.55 |
| CHEMBL4466702 | — | EC50 | = | 0.0284 | nM | 10.55 |
| CHEMBL4446161 | — | EC50 | = | 0.0807 | nM | 10.09 |
| CHEMBL3360467 | — | EC50 | = | 0.0082 | nM | - |
| CHEMBL4444885 | — | EC50 | = | 0.0044 | nM | - |
| CHEMBL4483702 | — | EC50 | = | 0.0057 | nM | - |
| CHEMBL4465921 | — | EC50 | = | 0.0034 | nM | - |
| CHEMBL4567354 | — | EC50 | = | 0.0056 | nM | - |
| CHEMBL4448604 | — | EC50 | = | 0.0093 | nM | - |
| CHEMBL4533823 | — | EC50 | = | 0.0062 | nM | - |
| CHEMBL4563742 | — | EC50 | = | 0.0066 | nM | - |
| CHEMBL4531684 | — | EC50 | = | 0.0078 | nM | - |
| CHEMBL4476378 | — | EC50 | = | 0.0081 | nM | - |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.0081 | nM | - |
| CHEMBL4471986 | — | EC50 | = | 0.0072 | nM | - |