Assay Detail
Binding
CHEMBL4359200
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Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.59 | 9.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476378 | — | — | 1 | 9.94 |
| CHEMBL4563742 | — | — | 1 | 9.85 |
| CHEMBL4531684 | — | — | 1 | 9.72 |
| CHEMBL4446161 | — | — | 1 | 9.48 |
| CHEMBL4533823 | — | — | 1 | 9.01 |
| CHEMBL4549709 | — | — | 1 | 8.83 |
| CHEMBL4483702 | — | — | 1 | 8.48 |
| CHEMBL4567354 | — | — | 1 | 8.36 |
| CHEMBL4465921 | — | — | 1 | 8.35 |
| CHEMBL4448604 | — | — | 1 | 8.05 |
| CHEMBL4444885 | — | — | 1 | 7.92 |
| CHEMBL3360467 | — | — | 1 | 7.50 |
| CHEMBL4579455 | — | — | 1 | 7.46 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476378 | — | EC50 | = | 0.1145 | nM | 9.94 |
| CHEMBL4563742 | — | EC50 | = | 0.1406 | nM | 9.85 |
| CHEMBL4531684 | — | EC50 | = | 0.1884 | nM | 9.72 |
| CHEMBL4446161 | — | EC50 | = | 0.3273 | nM | 9.48 |
| CHEMBL4533823 | — | EC50 | = | 0.9698 | nM | 9.01 |
| CHEMBL4549709 | — | EC50 | = | 1.471 | nM | 8.83 |
| CHEMBL4483702 | — | EC50 | = | 3.33 | nM | 8.48 |
| CHEMBL4567354 | — | EC50 | = | 4.365 | nM | 8.36 |
| CHEMBL4465921 | — | EC50 | = | 4.519 | nM | 8.35 |
| CHEMBL4448604 | — | EC50 | = | 8.912 | nM | 8.05 |
| CHEMBL4444885 | — | EC50 | = | 12.16 | nM | 7.92 |
| CHEMBL3360467 | — | EC50 | = | 31.99 | nM | 7.50 |
| CHEMBL4579455 | — | EC50 | = | 35.08 | nM | 7.46 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 52.85 | nM | 7.28 |