Assay Detail
Binding
CHEMBL4359201
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Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.35 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476378 | — | — | 1 | 9.18 |
| CHEMBL4531684 | — | — | 1 | 8.99 |
| CHEMBL4563742 | — | — | 1 | 8.97 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 7.31 |
| CHEMBL3360467 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476378 | — | EC50 | = | 0.6645 | nM | 9.18 |
| CHEMBL4531684 | — | EC50 | = | 1.027 | nM | 8.99 |
| CHEMBL4563742 | — | EC50 | = | 1.061 | nM | 8.97 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 49.4 | nM | 7.31 |
| CHEMBL3360467 | — | EC50 | = | 48.79 | nM | 7.31 |