Assay Detail
Binding
CHEMBL4359664
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Binding affinity to human C-terminal thrombin cleavage site-fused/6xHis-tagged JAK2 JH2 pseudokinase domain W777A/F974AH/V617F triple mutant (536 to 812 residues) expressed in baculovirus infected sf9 insect cells by microscale thermophoresis assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.38 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4525245 | — | — | 1 | 6.64 |
| CHEMBL4476380 | — | — | 1 | 6.40 |
| CHEMBL4449644 | — | — | 1 | 6.37 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4525245 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL4476380 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL4449644 | — | Kd | = | 430.0 | nM | 6.37 |
| CHEMBL191003 | JNJ-7706621 | Kd | = | 820.0 | nM | 6.09 |