Assay Detail
Binding
CHEMBL4359677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length HSP90 alpha expressed in Escherichia coli cells after 1 hr by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.74 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.92 |
| CHEMBL1195136 | SNX 5422 | 2.0 | 1 | 7.42 |
| CHEMBL4436271 | — | — | 1 | 7.16 |
| CHEMBL4460245 | — | — | 1 | 7.14 |
| CHEMBL4446403 | — | — | 1 | 6.79 |
| CHEMBL4534534 | — | — | 1 | 5.90 |
| CHEMBL4574129 | — | — | 1 | 5.82 |
| CHEMBL4457759 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1195136 | SNX 5422 | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4436271 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4460245 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4446403 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4534534 | — | IC50 | = | 1258.0 | nM | 5.90 |
| CHEMBL4574129 | — | IC50 | = | 1506.0 | nM | 5.82 |
| CHEMBL4457759 | — | IC50 | = | 1702.0 | nM | 5.77 |