Assay Detail
Functional
CHEMBL4360198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.10 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.89 |
| CHEMBL4448067 | — | — | 1 | 6.77 |
| CHEMBL4561563 | — | — | 1 | 6.60 |
| CHEMBL4446399 | — | — | 1 | 6.48 |
| CHEMBL4466747 | — | — | 1 | 6.31 |
| CHEMBL4578684 | — | — | 1 | 6.11 |
| CHEMBL4573893 | — | — | 1 | 6.06 |
| CHEMBL4463975 | — | — | 1 | 6.01 |
| CHEMBL4556665 | — | — | 1 | 5.92 |
| CHEMBL4473124 | — | — | 1 | 5.87 |
| CHEMBL4589048 | — | — | 1 | 5.85 |
| CHEMBL4570379 | — | — | 1 | 5.66 |
| CHEMBL4581183 | — | — | 1 | 5.65 |
| CHEMBL4472262 | — | — | 1 | 5.54 |
| CHEMBL4436984 | — | — | 1 | 5.43 |
| CHEMBL4469676 | — | — | 1 | 5.39 |
| CHEMBL4443271 | — | — | 1 | 5.37 |
| CHEMBL4532578 | — | — | 1 | 5.25 |
| CHEMBL4559208 | — | — | 1 | 5.22 |
| CHEMBL4450289 | — | — | 1 | - |
| CHEMBL4570461 | — | — | 1 | - |
| CHEMBL4446817 | — | — | 1 | - |
| CHEMBL4449969 | — | — | 1 | - |
| CHEMBL4573476 | — | — | 1 | - |
| CHEMBL4460883 | — | — | 1 | - |
| CHEMBL4454133 | — | — | 1 | - |
| CHEMBL4552113 | — | — | 1 | - |
| CHEMBL4522095 | — | — | 1 | - |
| CHEMBL4460575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4448067 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4561563 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4446399 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4466747 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4578684 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4573893 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4463975 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4556665 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4473124 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4589048 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4570379 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4581183 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4472262 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4436984 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4469676 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4443271 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL4532578 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL4559208 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL4450289 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4570461 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4446817 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4449969 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4573476 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4460883 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4454133 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4552113 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4522095 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4460575 | — | IC50 | > | 20000.0 | nM | - |