Assay Detail
ADMET
CHEMBL4361376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.93 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551160 | — | — | 1 | 5.79 |
| CHEMBL4525362 | — | — | 1 | 5.08 |
| CHEMBL4452064 | — | — | 1 | 4.68 |
| CHEMBL4437740 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4551160 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL4525362 | — | Ki | = | 8280.0 | nM | 5.08 |
| CHEMBL4452064 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL4437740 | — | Ki | = | 70600.0 | nM | 4.15 |