Assay Detail
Binding
CHEMBL4361377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.01 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551160 | — | — | 1 | 8.27 |
| CHEMBL4525362 | — | — | 1 | 7.47 |
| CHEMBL4452064 | — | — | 1 | 6.74 |
| CHEMBL4437740 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4551160 | — | Ki | = | 5.36 | nM | 8.27 |
| CHEMBL4525362 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4452064 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL4437740 | — | Ki | = | 2900.0 | nM | 5.54 |