Assay Detail
Binding
CHEMBL4361657
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Inhibition of recombinant human carbonic anhydrase 12 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.40 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519372 | — | — | 1 | 7.52 |
| CHEMBL4586124 | — | — | 1 | 7.46 |
| CHEMBL4448721 | — | — | 1 | 7.35 |
| CHEMBL3322093 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519372 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL4586124 | — | Ki | = | 34.7 | nM | 7.46 |
| CHEMBL4448721 | — | Ki | = | 44.5 | nM | 7.35 |
| CHEMBL3322093 | — | Ki | = | 56.4 | nM | 7.25 |