Assay Detail
Binding
CHEMBL4361684
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Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membrane
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.11 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4543232 | — | — | 1 | 6.00 |
| CHEMBL4472986 | — | — | 1 | 5.97 |
| CHEMBL4462607 | — | — | 1 | 5.64 |
| CHEMBL4571320 | — | — | 1 | 5.62 |
| CHEMBL4453342 | — | — | 1 | 5.47 |
| CHEMBL4444866 | — | — | 1 | 5.08 |
| CHEMBL4447564 | — | — | 1 | 4.89 |
| CHEMBL4441630 | — | — | 1 | 4.64 |
| CHEMBL4435435 | — | — | 1 | 4.63 |
| CHEMBL4565381 | — | — | 1 | 4.55 |
| CHEMBL4460815 | — | — | 1 | 4.48 |
| CHEMBL4530364 | — | — | 1 | 4.37 |
| CHEMBL4532589 | — | — | 1 | - |
| CHEMBL4556523 | — | — | 1 | - |
| CHEMBL4581470 | — | — | 1 | - |
| CHEMBL4476500 | — | — | 1 | - |
| CHEMBL298826 | (-)-EPIBATIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4543232 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4472986 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL4462607 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL4571320 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL4453342 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL4444866 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL4447564 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL4441630 | — | Ki | = | 22900.0 | nM | 4.64 |
| CHEMBL4435435 | — | Ki | = | 23400.0 | nM | 4.63 |
| CHEMBL4565381 | — | Ki | = | 27900.0 | nM | 4.55 |
| CHEMBL4460815 | — | Ki | = | 33200.0 | nM | 4.48 |
| CHEMBL4530364 | — | Ki | = | 43100.0 | nM | 4.37 |
| CHEMBL4532589 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4556523 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4581470 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4476500 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL298826 | (-)-EPIBATIDINE | Ki | - | — | - |