Assay Detail
Functional
CHEMBL4361707
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Antiplasmodial activity against chloroquine-resistant asexual blood stage of Plasmodium falciparum K1 by LDH assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.51 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536176 | — | — | 1 | 6.82 |
| CHEMBL4458564 | — | — | 1 | 6.75 |
| CHEMBL4548998 | — | — | 1 | 6.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.69 |
| CHEMBL4444771 | — | — | 1 | 6.34 |
| CHEMBL4457955 | — | — | 1 | 5.74 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536176 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4458564 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4548998 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL4444771 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4457955 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL361497 | ARTESUNATE | IC50 | - | — | - |