Assay Detail
Functional
CHEMBL4361849
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 to 72 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM<sup>+</sup>/CD133<sup>+</sup> cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.20 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464443 | GONIOTHALAMIN | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464443 | GONIOTHALAMIN | IC50 | = | 625.0 | nM | 6.20 |