Assay Detail
Binding
CHEMBL4361967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Estradiol 17-beta-dehydrogenase 2 (CHEMBL1914268) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.84 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4513439 | — | — | 1 | 8.05 |
| CHEMBL4447938 | — | — | 1 | 8.00 |
| CHEMBL4518587 | — | — | 1 | 8.00 |
| CHEMBL4441313 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4513439 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4447938 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4518587 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4441313 | — | IC50 | = | 50.0 | nM | 7.30 |