Assay Detail
Binding
CHEMBL4361968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat 17beta-HSD1 expressed in HEK293 cells using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Estradiol 17-beta-dehydrogenase 1 (CHEMBL1914267) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.70 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518587 | — | — | 1 | 8.05 |
| CHEMBL4441313 | — | — | 1 | 6.46 |
| CHEMBL4513439 | — | — | 1 | 6.41 |
| CHEMBL4447938 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518587 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4441313 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4513439 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL4447938 | — | IC50 | = | 1334.0 | nM | 5.88 |