Assay Detail
ADMET
CHEMBL4361981
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Inhibition of electric eel AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine iodide as substrate measured for 125 secs by Ellman's method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.19 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.64 |
| CHEMBL4475228 | — | — | 1 | 7.12 |
| CHEMBL4588525 | — | — | 1 | 6.96 |
| CHEMBL4575976 | — | — | 1 | 6.96 |
| CHEMBL4572757 | — | — | 1 | 6.92 |
| CHEMBL4531167 | — | — | 1 | 6.85 |
| CHEMBL1783191 | — | — | 1 | 6.80 |
| CHEMBL4555120 | — | — | 1 | 6.77 |
| CHEMBL4535585 | — | — | 1 | 6.72 |
| CHEMBL4589250 | — | — | 1 | 6.68 |
| CHEMBL4545701 | — | — | 1 | 6.47 |
| CHEMBL4483710 | — | — | 1 | 6.43 |
| CHEMBL4521755 | — | — | 1 | 6.40 |
| CHEMBL4076034 | — | — | 1 | 6.19 |
| CHEMBL3182739 | — | — | 1 | 6.06 |
| CHEMBL4550977 | — | — | 1 | 5.80 |
| CHEMBL4469822 | — | — | 1 | 5.80 |
| CHEMBL4549672 | — | — | 1 | 5.75 |
| CHEMBL4536715 | — | — | 1 | 5.68 |
| CHEMBL4534033 | — | — | 1 | 5.64 |
| CHEMBL4564873 | — | — | 1 | 5.60 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.52 |
| CHEMBL4439554 | — | — | 1 | 5.52 |
| CHEMBL4450123 | — | — | 1 | 5.50 |
| CHEMBL4560263 | — | — | 1 | 4.62 |
| CHEMBL4517722 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4475228 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL4588525 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4575976 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4572757 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4531167 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1783191 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4555120 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4535585 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4589250 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL4545701 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL4483710 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4521755 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL4076034 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL3182739 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL4550977 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4469822 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4549672 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4536715 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL4534033 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL4564873 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL659 | GALANTAMINE | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4439554 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4450123 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL4560263 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL4517722 | — | Ki | = | 39000.0 | nM | 4.41 |