Assay Detail
ADMET
CHEMBL4361982
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Inhibition of electric eel AChE assessed as dissociation constant for enzyme-substrate-inhibitor complex using acetylthiocholine iodide as substrate measured for 125 secs by Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.43 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4575976 | — | — | 1 | 7.50 |
| CHEMBL4555120 | — | — | 1 | 7.26 |
| CHEMBL4572757 | — | — | 1 | 7.24 |
| CHEMBL4475228 | — | — | 1 | 7.12 |
| CHEMBL4589250 | — | — | 1 | 7.11 |
| CHEMBL4483710 | — | — | 1 | 7.09 |
| CHEMBL4531167 | — | — | 1 | 7.00 |
| CHEMBL4588525 | — | — | 1 | 6.96 |
| CHEMBL1783191 | — | — | 1 | 6.92 |
| CHEMBL4545701 | — | — | 1 | 6.89 |
| CHEMBL4521755 | — | — | 1 | 6.77 |
| CHEMBL4535585 | — | — | 1 | 6.72 |
| CHEMBL4076034 | — | — | 1 | 6.68 |
| CHEMBL3182739 | — | — | 1 | 6.23 |
| CHEMBL4550977 | — | — | 1 | 6.21 |
| CHEMBL4469822 | — | — | 1 | 6.21 |
| CHEMBL4536715 | — | — | 1 | 6.09 |
| CHEMBL4439554 | — | — | 1 | 5.75 |
| CHEMBL4564873 | — | — | 1 | 5.72 |
| CHEMBL4549672 | — | — | 1 | 5.60 |
| CHEMBL4534033 | — | — | 1 | 5.52 |
| CHEMBL4560263 | — | — | 1 | 4.70 |
| CHEMBL4517722 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4575976 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4555120 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL4572757 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4475228 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL4589250 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL4483710 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL4531167 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4588525 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1783191 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4545701 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL4521755 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4535585 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4076034 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3182739 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL4550977 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL4469822 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL4536715 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL4439554 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4564873 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4549672 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL4534033 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4560263 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL4517722 | — | Ki | = | 23000.0 | nM | 4.64 |