Assay Detail
Functional
CHEMBL4362018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhibition of cAMP production incubated for 15 mins by competitive enzyme-linked immunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y<sub>14</sub> receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.46 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436879 | — | — | 1 | 8.75 |
| CHEMBL1800685 | PPTN | — | 1 | 8.70 |
| CHEMBL4577585 | — | — | 1 | 8.50 |
| CHEMBL4538561 | — | — | 1 | 8.36 |
| CHEMBL4455311 | — | — | 1 | 8.34 |
| CHEMBL4458922 | — | — | 1 | 8.30 |
| CHEMBL4526840 | — | — | 1 | 8.30 |
| CHEMBL4544516 | — | — | 1 | - |
| CHEMBL4444277 | — | — | 1 | - |
| CHEMBL4585569 | — | — | 1 | - |
| CHEMBL4568716 | — | — | 1 | - |
| CHEMBL4459825 | — | — | 1 | - |
| CHEMBL4548774 | — | — | 1 | - |
| CHEMBL4450096 | — | — | 1 | - |
| CHEMBL4475814 | — | — | 1 | - |
| CHEMBL4449331 | — | — | 1 | - |
| CHEMBL4541044 | — | — | 1 | - |
| CHEMBL4471193 | — | — | 1 | - |
| CHEMBL4588599 | — | — | 1 | - |
| CHEMBL4444167 | — | — | 1 | - |
| CHEMBL4483489 | — | — | 1 | - |
| CHEMBL4474050 | — | — | 1 | - |
| CHEMBL4445922 | — | — | 1 | - |
| CHEMBL4443140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436879 | — | IC50 | = | 1.77 | nM | 8.75 |
| CHEMBL1800685 | PPTN | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL4577585 | — | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL4538561 | — | IC50 | = | 4.35 | nM | 8.36 |
| CHEMBL4455311 | — | IC50 | = | 4.54 | nM | 8.34 |
| CHEMBL4458922 | — | IC50 | = | 4.95 | nM | 8.30 |
| CHEMBL4526840 | — | IC50 | = | 5.06 | nM | 8.30 |
| CHEMBL4544516 | — | IC50 | - | — | - | |
| CHEMBL4444277 | — | IC50 | - | — | - | |
| CHEMBL4585569 | — | IC50 | - | — | - | |
| CHEMBL4568716 | — | IC50 | - | — | - | |
| CHEMBL4459825 | — | IC50 | - | — | - | |
| CHEMBL4548774 | — | IC50 | - | — | - | |
| CHEMBL4450096 | — | IC50 | - | — | - | |
| CHEMBL4475814 | — | IC50 | - | — | - | |
| CHEMBL4449331 | — | IC50 | - | — | - | |
| CHEMBL4541044 | — | IC50 | - | — | - | |
| CHEMBL4471193 | — | IC50 | - | — | - | |
| CHEMBL4588599 | — | IC50 | - | — | - | |
| CHEMBL4444167 | — | IC50 | - | — | - | |
| CHEMBL4483489 | — | IC50 | - | — | - | |
| CHEMBL4474050 | — | IC50 | - | — | - | |
| CHEMBL4445922 | — | IC50 | - | — | - | |
| CHEMBL4443140 | — | IC50 | - | — | - |