Assay Detail
Binding
CHEMBL4362236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CA12 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.29 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL4475456 | — | — | 1 | 8.34 |
| CHEMBL4466506 | — | — | 1 | 8.16 |
| CHEMBL4555163 | — | — | 1 | 8.04 |
| CHEMBL4449914 | — | — | 1 | 7.99 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4547526 | — | — | 1 | 7.13 |
| CHEMBL4517297 | — | — | 1 | 7.06 |
| CHEMBL4442248 | — | — | 1 | 6.19 |
| CHEMBL4442193 | — | — | 1 | 6.15 |
| CHEMBL4521441 | — | — | 1 | 6.10 |
| CHEMBL4569133 | — | — | 1 | 5.99 |
| CHEMBL4467560 | — | — | 1 | - |
| CHEMBL4547535 | — | — | 1 | - |
| CHEMBL4566244 | — | — | 1 | - |
| CHEMBL4573205 | — | — | 1 | - |
| CHEMBL3740241 | — | — | 1 | - |
| CHEMBL4445398 | — | — | 1 | - |
| CHEMBL4572128 | — | — | 1 | - |
| CHEMBL4452436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4475456 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4466506 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL4555163 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL4449914 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4547526 | — | Ki | = | 74.8 | nM | 7.13 |
| CHEMBL4517297 | — | Ki | = | 86.3 | nM | 7.06 |
| CHEMBL4442248 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL4442193 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL4521441 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL4569133 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL4467560 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4547535 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4566244 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4573205 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3740241 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4445398 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4572128 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4452436 | — | Ki | > | 100.0 | nM | - |