Assay Detail
Functional
CHEMBL4362327
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Antiproliferative activity against human HH cells assessed as reduction in cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HH |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.84 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4452230 | — | — | 1 | 5.62 |
| CHEMBL4451642 | — | — | 1 | 5.28 |
| CHEMBL4544858 | — | — | 1 | 4.93 |
| CHEMBL4445279 | — | — | 1 | 4.91 |
| CHEMBL3578214 | — | — | 1 | 4.86 |
| CHEMBL3578215 | — | — | 1 | 4.83 |
| CHEMBL4469733 | — | — | 1 | 4.76 |
| CHEMBL4464645 | — | — | 1 | 4.76 |
| CHEMBL4580182 | — | — | 1 | 4.74 |
| CHEMBL4463671 | — | — | 1 | 4.68 |
| CHEMBL4446463 | — | — | 1 | 4.37 |
| CHEMBL4573583 | — | — | 1 | 4.31 |
| CHEMBL4444475 | — | — | 1 | - |
| CHEMBL4568918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4452230 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4451642 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4544858 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL4445279 | — | IC50 | = | 12440.0 | nM | 4.91 |
| CHEMBL3578214 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3578215 | — | IC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL4469733 | — | IC50 | = | 17310.0 | nM | 4.76 |
| CHEMBL4464645 | — | IC50 | = | 17260.0 | nM | 4.76 |
| CHEMBL4580182 | — | IC50 | = | 18170.0 | nM | 4.74 |
| CHEMBL4463671 | — | IC50 | = | 21080.0 | nM | 4.68 |
| CHEMBL4446463 | — | IC50 | = | 43120.0 | nM | 4.37 |
| CHEMBL4573583 | — | IC50 | = | 48530.0 | nM | 4.31 |
| CHEMBL4444475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4568918 | — | IC50 | > | 100000.0 | nM | - |