Assay Detail
Functional
CHEMBL4363239
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Antiproliferative activity against human CL97 cells harbouring EGFR G719A/T790M mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CL97 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.33 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.00 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.00 |
| CHEMBL4443455 | — | — | 1 | 6.30 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.00 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4443455 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL939 | GEFITINIB | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL553 | ERLOTINIB | IC50 | > | 20000.0 | nM | - |