Assay Detail
Binding
CHEMBL4363584
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.80 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450666 | — | — | 1 | 8.80 |
| CHEMBL4455825 | — | — | 1 | 8.59 |
| CHEMBL4453623 | — | — | 1 | 8.47 |
| CHEMBL4577187 | — | — | 1 | 8.43 |
| CHEMBL4470503 | — | — | 1 | 8.42 |
| CHEMBL4516972 | — | — | 1 | 8.35 |
| CHEMBL4440932 | — | — | 1 | 8.34 |
| CHEMBL4565471 | — | — | 1 | 8.32 |
| CHEMBL4476050 | — | — | 1 | 8.32 |
| CHEMBL4475477 | — | — | 1 | 8.31 |
| CHEMBL4540833 | — | — | 1 | 8.28 |
| CHEMBL4569748 | — | — | 1 | 8.24 |
| CHEMBL4446872 | — | — | 1 | 8.23 |
| CHEMBL4475435 | — | — | 1 | 8.17 |
| CHEMBL4593200 | — | — | 1 | 8.12 |
| CHEMBL4472013 | — | — | 1 | 8.11 |
| CHEMBL4577408 | — | — | 1 | 8.10 |
| CHEMBL4457120 | — | — | 1 | 8.07 |
| CHEMBL4464496 | — | — | 1 | 8.06 |
| CHEMBL4586855 | — | — | 1 | 8.05 |
| CHEMBL4521611 | — | — | 1 | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4550339 | — | — | 1 | 7.88 |
| CHEMBL4538471 | — | — | 1 | 7.74 |
| CHEMBL4440330 | — | — | 1 | 7.70 |
| CHEMBL4573177 | — | — | 1 | 7.58 |
| CHEMBL4444078 | — | — | 1 | 7.55 |
| CHEMBL4543874 | — | — | 1 | 7.52 |
| CHEMBL4462700 | — | — | 1 | 7.49 |
| CHEMBL4461778 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450666 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4455825 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4453623 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4577187 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4470503 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4516972 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4440932 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4565471 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4476050 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4475477 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4540833 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL4569748 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4446872 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL4475435 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL4593200 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL4472013 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4577408 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL4457120 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4464496 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL4586855 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL4521611 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4550339 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL4538471 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL4440330 | — | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL4573177 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL4444078 | — | Ki | = | 27.9 | nM | 7.55 |
| CHEMBL4543874 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4462700 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL4461778 | — | Ki | = | 34.9 | nM | 7.46 |
| CHEMBL4469501 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL4525693 | — | Ki | = | 38.2 | nM | 7.42 |
| CHEMBL4586708 | — | Ki | = | 40.6 | nM | 7.39 |
| CHEMBL4474463 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL4519299 | — | Ki | = | 56.4 | nM | 7.25 |
| CHEMBL4443290 | — | Ki | = | 57.3 | nM | 7.24 |
| CHEMBL4482951 | — | Ki | = | 61.7 | nM | 7.21 |
| CHEMBL4474384 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL4448003 | — | Ki | = | 94.4 | nM | 7.03 |
| CHEMBL4461506 | — | Ki | = | 153.8 | nM | 6.81 |
| CHEMBL4463775 | — | Ki | = | 9103.9 | nM | 5.04 |